The ADRION area is characterized by low innovation performance, limited capacity of SMEs, inadequate cooperation among companies and research institutes, low synergies among agro-food and tourism sector and low implementation of environmentally – friendly farming practices. On the other hand, according to the ADRION PROGRAMME SWOT ANALYSIS, there are some strong points, such as the existence of quality agro-food products, the existence of a number of competitive and highly active research and innovation clusters, albeit with poor intraregional joint activities, and also the existence of RIS3, where transnational cooperation can focus on, in order to find solutions in the common problem of SMEs extroversion. The field is complex and requires much learning in terms of internationalization, access to market, financing, networking, innovation capacity, business transfer, entrepreneurship, cross – border & cross – sector co-operation, and environmentally – friendly farming practices . It also entails incorporation of new forms of SME development, such as design, eco-conception and corporate social responsibility. The project focuses on the development of links and synergies between farmers, agro-food enterprises, Research Institutes and Public Authorities, for a) the promotion of agro-food products’ extroversion, b) the development of agro-food companies’ internalization, and c) the promotion of environmentally – friendly farming practices. Project’s main outputs are: 1)SWOT Analysis about innovation, business cooperation and protection of the environment in the participant countries’ agro-food sector, 2) a Transnational Innovative Agro-food Network, 3) a Virtual Business Innovation & Entrepreneurship Center (VIBIEC),offering support through e-incubators, e-business network platform, and other self-assesment tools, 4)publicity actions, 5) capitalization activities of project’s outcomes and tools, 6)project’s management, quality assurance and evaluation.